Studies On Genetic Polymorphism Of Drug Metabolizing Enzymes And Other Essay

Studies On Genetic Polymorphism Of Drug Metabolizing Enzymes And Other Relevant Genes In Type 2 Diabetes Mellitus - Essay Example Overall, this kind of "out breeding" rendered Arab populations more susceptible to genetic disorders when it comes to consanguinity. This may be explained by the fact that the out-breeding introduced a variety of deleterious recessive alleles common among other populations apart from the alleles already common among Arabs. Therefore, data obtained from other ethnic groups cannot be applied to the Arab population. There is no previous report available on the genetic polymorphism of CYP2C8, CYP2C9, CYP2C19, CYP3A4, CYP3A5, CYP11B1, CYP11B2, Haptoglobin, ACE, PPARG2, TCF7L2, Haptoglobin and IL-1RA and their association with T2DM in the Arab population. Hence, the present research project has been undertaken with the aim to establish the genetic polymorphism of these genes in the Arab population and to carry out the Association study of genetic variants of these genes with T2DM. Relevance The proposed study will facilitate improvement of the drug therapy and diagnosis of T2DM in the Arab population residing in the UAE. The study may find new genetic risk factors of T2DM in Arabs which can be utilized as targets for early diagnosis of T2DM, screening and more personalized medical therapy and potential development of new antidiabetic drugs. The primary objective of this project falls within the Abu Dhabi Vision 2030. This, this study will lead to substantial improvements in quality of life for affected individuals and a reduction inof healthcare costs.... in Abu Dhabi with the aim of studying the Genetic Polymorphism Of Drug Metabolizing Enzymes and Other Relevant Genes In Type 2 Diabetes Mellitus and related Complications in Arabs Residing in the UAE. Our long term goals are to utilize the outcome of the study in individualization of drug therapy and molecular diagnosis of T2DM in the Arab population residing in the UAE, to develop new techniques for molecular diagnosis of T2DM, to find new genetic risk factors of T2DM in Arabs which will be utilized as markers of early diagnosis of T2DM as well as targets for development of new antidiabetic drugs, to find the prevalence of genetic polymorphism of the above mentioned genes in the Saudi Arab population and to work towards the individualization of drug therapy for T2DM based on the genetic profile of patients. Our immediate goals are to study allele and genotype frequencies of CYP2C8, CYP2C9, CYP2C19, CYP3A4, CYP3A5, CYP11B1, CYP11B2, Haptoglobin, ACE, PPARG2, TCF7L2, and IL-1RA in the Saudi Arabian population, to carry out the association study of genetic variants in these genes with Type 2 Diabetes Mellitus and related hypertension and nephropathy, as well as to compare the allele and genotype frequencies found in Arabs with those in other ethnic groups. Project Description Background DRUG METABOLISM AND CYTOCHROME P450 (CYP) Cytochromes P450 (CYPs) represent a super family of heme-containing proteins, found primarily in the liver. Eighteen gene families, consisting of 43 subfamilies, 57 active and 58 pseudogenes, exist in the human (Nelson et al, 2004). The members of the first 3 families (CYP1, 2 and3) are involved in the metabolism of drugs. Hence, these CYPs play an important role in the pharmacokinetics of drugs. It is now well documented that large